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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Did you know?
Tobacco depletes the body of vitamins A, C, and E, which can result in any of the following: dry hair, dry skin, dry eyes, poor growth, night blindness, abscesses, insomnia, fatigue, reproductive system problems, sinusitis, pneumonia, frequent respiratory problems, skin disorders, weight loss, rickets, osteomalacia, nervousness, muscle spasms, leg cramps, extremity numbness, bone malformations, decayed teeth, difficulty in walking, irritability, restlessness, profuse sweating, increased uric acid (gout), joint damage, damaged red blood cells, destruction of nerves, infertility, miscarriage, and many types of cancer.
Astronaut Piers Sellers during the third spacewalk of STS-121, a demonstration of orbiter heat shiel
Comparison of Chronometric Techniques
Performing Transmission-Based Precaution: Isolation Techniques
Fascial stretching techniques. (A) Cross-hand dual direction stretch. (B) Pin and stretch with the ...
Two techniques for holding and inserting an otoscope
Simple Decorating Techniques: Cake comb