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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Illness; diuretics; laxative abuse; hot weather; exercise; sweating; caffeine; alcoholic beverages; starvation diets; inadequate carbohydrate consumption; and diets high in protein, salt, or fiber can cause people to become dehydrated.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.