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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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Illicit drug use costs the United States approximately $181 billion every year.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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People with alcoholism are at a much greater risk of malnutrition than are other people and usually exhibit low levels of most vitamins (especially folic acid). This is because alcohol often takes the place of 50% of their daily intake of calories, with little nutritional value contained in it.