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By definition, when a medication is administered intravenously, its bioavailability is 100%.
Bacteria have flourished on the earth for over three billion years. They were the first life forms on the planet.
When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
To prove that stomach ulcers were caused by bacteria and not by stress, a researcher consumed an entire laboratory beaker full of bacterial culture. After this, he did indeed develop stomach ulcers, and won the Nobel Prize for his discovery.
Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.