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Although the Roman numeral for the number 4 has always been taught to have been "IV," according to historians, the ancient Romans probably used "IIII" most of the time. This is partially backed up by the fact that early grandfather clocks displayed IIII for the number 4 instead of IV. Early clockmakers apparently thought that the IIII balanced out the VIII (used for the number 8) on the clock face and that it just looked better.
On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.
Human kidneys will clean about 1 million gallons of blood in an average lifetime.
The most destructive flu epidemic of all times in recorded history occurred in 1918, with approximately 20 million deaths worldwide.