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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Thyroid conditions cause a higher risk of fibromyalgia and chronic fatigue syndrome.
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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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The longest a person has survived after a heart transplant is 24 years.