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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Inotropic therapy does not have a role in the treatment of most heart failure patients. These drugs can make patients feel and function better but usually do not lengthen the predicted length of their lives.
Approximately 500,000 babies are born each year in the United States to teenage mothers.
More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.

