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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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The strongest synthetic topical retinoid drug available, tazarotene, is used to treat sun-damaged skin, acne, and psoriasis.
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The average adult has about 21 square feet of skin.
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More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.