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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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Excessive alcohol use costs the country approximately $235 billion every year.
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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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In 1864, the first barbiturate (barbituric acid) was synthesized.