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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
Cytomegalovirus affects nearly the same amount of newborns every year as Down syndrome.
When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.