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Warfarin was developed as a consequence of the study of a strange bleeding disorder that suddenly occurred in cattle on the northern prairies of the United States in the early 1900s.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.