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ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.
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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
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The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.