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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.
Medication errors are more common among seriously ill patients than with those with minor conditions.
More than 30% of American adults, and about 12% of children utilize health care approaches that were developed outside of conventional medicine.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.