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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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The average adult has about 21 square feet of skin.