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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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The horizontal fraction bar was introduced by the Arabs.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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All adults should have their cholesterol levels checked once every 5 years. During 2009–2010, 69.4% of Americans age 20 and older reported having their cholesterol checked within the last five years.