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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
According to the FDA, adverse drug events harmed or killed approximately 1,200,000 people in the United States in the year 2015.
The FDA recognizes 118 routes of administration.
Every 10 seconds, a person in the United States goes to the emergency room complaining of head pain. About 1.2 million visits are for acute migraine attacks.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.