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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
By definition, when a medication is administered intravenously, its bioavailability is 100%.
Fewer than 10% of babies are born on their exact due dates, 50% are born within 1 week of the due date, and 90% are born within 2 weeks of the date.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.


