Which of the following are side effects of dornase alfa ...

[j.rubin]

Which of the following are side effects of dornase alfa administration? 1. Allergic reactions due to antibody production in the patient against dornase alfa 2. Chest pain 3. Rash 4. Laryngitis
 
  a. 1, 2, and 3 only
  b. 1, 3, and 4 only
  c. 2, 3, and 4 only
  d. 1, 2, 3, and 4

Question 2

Which of the following FEV1 values indicates severe compromise of expiratory airflow that may contraindicate the use of mucoactive therapy?
 
  a. Less than 65
  b. Less than 55
  c. Less than 35
  d. Less than 25

[dlook33]

Answer to Question 1

ANS: C
Common side effects associated with dornase alfa have included pharyngitis and voice altera-tion, laryngitis, rash, chest pain, and conjunctivitis.

Answer to Question 2

ANS: D
Generally, if the FEV1 is less than 25 of predicted, it becomes difficult to mobilize and expec-torate secretions.

[j.rubin]

TYSM

[Sarahjh]

Excellent