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As the western states of America were settled, pioneers often had to drink rancid water from ponds and other sources. This often resulted in chronic diarrhea, causing many cases of dehydration and death that could have been avoided if clean water had been available.
Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
Vaccines prevent between 2.5 and 4 million deaths every year.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.

