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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Approximately 500,000 babies are born each year in the United States to teenage mothers.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
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Medication errors are three times higher among children and infants than with adults.