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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.
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The FDA recognizes 118 routes of administration.
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There are approximately 3 million unintended pregnancies in the United States each year.
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The strongest synthetic topical retinoid drug available, tazarotene, is used to treat sun-damaged skin, acne, and psoriasis.
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In 1864, the first barbiturate (barbituric acid) was synthesized.