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In 1864, the first barbiturate (barbituric acid) was synthesized.
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For pediatric patients, intravenous fluids are the most commonly cited products involved in medication errors that are reported to the USP.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.
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The National Institutes of Health have supported research into acupuncture. This has shown that acupuncture significantly reduced pain associated with osteoarthritis of the knee, when used as a complement to conventional therapies.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.