Bearing in mind the function of the bloodbrain barrier, dangers ...

[D2AR0N]

Bearing in mind the function of the bloodbrain barrier, dangers associated with administering large doses of water-soluble drugs relate primarily to the
 
  a. rapid development of tolerance.
  b. high risk of adverse systemic effects.
  c. liver's inability to metabolize water-soluble drugs.
  d. rapid passage into the brain increasing the risk of overdose.

Question 2

A patient diagnosed with schizophrenia has taken thiothixene (Navane) 5 mg/day for 4 years with good symptom control
 
  Today, the patient is admitted with paranoia and auditory hallucinations. The nurse should determine if the patient's symptoms are related to:
  a. not taking the drug as prescribed.
  b. activation of serotonin receptors.
  c. development of tolerance to the drug.
  d. an expected illness-exacerbation cycle.

[Animal_Goddess]

Answer to Question 1

B
Water-soluble drugs penetrate the bloodbrain barrier slowly and in insignificant amounts. A dose high enough to affect the brain would invariably cause adverse systemic side effects. The other effects are not related.

Answer to Question 2

A
When a patient does not respond to a drug, or when symptoms reappear after a good response to the drug, the nurse should assess for compliance. Is the patient taking the drug? Is the patient taking less of the drug than ordered? The other options are less relevant or of no value.

[D2AR0N]

Thanks for the timely response, appreciate it

[mochi09]

Gracias!