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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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Human stomach acid is strong enough to dissolve small pieces of metal such as razor blades or staples.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Medication errors are more common among seriously ill patients than with those with minor conditions.