Author Question: The nurse reviewing a medical record notes that high concentrations of methotrexate followed by ... (Read 121 times)

awywial · **on:** Jul 22, 2018

The nurse reviewing a medical record notes that high concentrations of methotrexate followed by leucovorin (citrovorum factor, folic acid) are being given to the client with cancer.

The nurse correctly interprets that the reason for therapy with leucovorin is to: 1. Preserve normal cells.
2. Promote protein synthesis.
3. Promote medication excretion.
4. Hasten the effect of the methotrexate.

Question 2

The nurse is reviewing the laboratory results of studies on a 4-month-old infant and notes that the human immunodeficiency virus (HIV) antibody test is positive. The nurse determines that this test result indicates which of the following?

1. The infant has HIV.
2. The infant is infected with the HIV virus.
3. The mother is infected with the HIV virus.
4. This is a significant result, indicating a repeat test in 1 month.

honnalora · **Reply #1 on:** Jul 22, 2018

Answer to Question 1

1

Rationale: The administration of leucovorin with methotrexate is known as leucovorin rescue. High concentrations of methotrexate cause harm and damage to normal cells. Leucovorin bypasses the metabolic block caused by methotrexate, thereby permitting normal cells to synthesize. Leucovorin rescue is potentially hazardous, because failure to administer leucovorin in the right dose at the right time can be fatal.

Answer to Question 2

3

Rationale: A positive HIV antibody test result in a child younger than 18 months indicates only that the mother is infected, because maternal IgG antibodies persist in infants for 6 to 9 months and, in some cases, as long as 18 months. The infant has HIV, the infant is infected with the HIV virus, and this is a significant result, indicating a repeat test in 1 month are incorrect in-terpretations of this laboratory result.