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Women are 50% to 75% more likely than men to experience an adverse drug reaction.
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Opium has influenced much of the world's most popular literature. The following authors were all opium users, of varying degrees: Lewis Carroll, Charles, Dickens, Arthur Conan Doyle, and Oscar Wilde.
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Side effects from substance abuse include nausea, dehydration, reduced productivitiy, and dependence. Though these effects usually worsen over time, the constant need for the substance often overcomes rational thinking.
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Illicit drug use costs the United States approximately $181 billion every year.
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In 1864, the first barbiturate (barbituric acid) was synthesized.