Answer to Question 1
Correct Answer: 1,2,3
Rationale 1: Ventricular hypertrophy occurs as a compensatory mechanism to heart failure.
Rationale 2: One of the fastest homeostatic responses to diminished cardiac output is activation of the sympathetic nervous system (SNS). The increased heart rate resulting from sympathetic activation is a normal compensatory mechanism that serves to increase cardiac output.
Rationale 3: When cardiac output in a patient with HF is diminished, blood flow to the kidneys is reduced.
Rationale 4: Vasopressin (antidiuretic hormone), which is elevated in HF patients, causes fluid retention and worsens this condition.
Rationale 5: Two pro-inflammatory substances, tumor necrosis factor (TNF) and interleukin, are found in high levels in patients with HF and are associated with a poor prognosis.
Answer to Question 2
Correct Answer: 1,2,3,5
Rationale 1: Uncontrolled hypertension is associated with the development of heart failure.
Rationale 2: Coronary artery disease is associated with the development of heart failure.
Rationale 3: Diabetes is associated with the development of heart failure.
Rationale 4: HIV is not associated with the development of heart failure.
Rationale 5: Mitral stenosis is associated with the development of heart failure.