The nurse administers medications by various routes of delivery. ...

[Pea0909berry]

The nurse administers medications by various routes of delivery. The nurse recognizes which route of administration as requiring higher dosages of drugs to achieve a therapeutic effect?
 
  1. Intravenous route
  2. Oral route
  3. Rectal route
  4. Sublingual route

Question 2

The patient receives a drug that is excreted in the bile. What will the best nursing assessment of the effect of this drug on the patient include?
 
  1. The effect of the drug will be a prolonged action.
  2. The effect of the drug will be increased side effects.
  3. The effect of the drug will be decreased side effects.
  4. The effect of the drug will be decreased.

[LP]

Answer to Question 1

Correct Answer: 2
Rationale: Oral medications pass into the hepatoportal circulation and may be completely metabolized before reaching the general circulation. This so-called first pass effect may necessitate the use of higher dosages of oral medications to achieve a therapeutic effect. None of the other routes, sublingual, rectal, or intravenous, are affected by the first-pass effect.

Answer to Question 2

Correct Answer: 1
Rationale: Most bile is circulated back to the liver so drugs secreted into the bile will be recirculated numerous times with the bile, resulting in a prolonged action of the drug. Bile-excreted drugs do not have a decreased effect, nor are side effects decreased. Side effects may or may not be increased; this is dose dependent.

[Pea0909berry]

Thanks for the timely response, appreciate it

[parshano]

Excellent