Author Question: Which of the following parameters would be most useful in calculating drug dosages for a child? ... (Read 61 times)

jenna1 · **on:** Jul 23, 2018

Which of the following parameters would be most useful in calculating drug dosages for a child?

a. Height
b. Weight
c. Age
d. Body surface area

Question 2

Which of the following enhance placental transfer of drugs? Select all that apply.

a. Lipid solubility
b. Nonionized nature of the substance
c. Lack of significant albumin binding
d. Increased diffusion distance
e. High molecular charge
f. High molecular weight
g. Higher maternal-to-fetal gradient
h. Increased placental blood flow

fdliggud · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: D
The body surface area (BSA) offers a precise way to calculate pediatric drug dosages, because it is an accurate reflection of many of the physiologic processes significant in transporting, bio-transforming, and eliminating drugs. The physiologic processes influenced by the BSA include the metabolic rate, extracellular fluid and total fluid volumes, cardiac output, and glomerular fil-tration rate (GFR).

Answer to Question 2

ANS: A, B, C, G, H
Factors that enhance the placental transfer of drugs include lipid solubility, nonionized substanc-es, lack of significant albumin binding, higher maternal-to-fetal gradient, and increased placental blood flow. Increased diffusion distance, high molecular charge, and high molecular weight are factors that inhibit placental transfer of drugs.