Which groups of antineoplastic medications have been extracted ...

[ts19998]

Which groups of antineoplastic medications have been extracted from plants?(Select all that apply.)
 
  1. Vinca alkaloids
  2. Topoisomerase inhibitors
  3. Taxanes
  4. Alkylating agents
  5. Antimetabolite agents

Question 2

A client is undergoing antineoplastic therapy with vincristine (Oncovin). Which statement by the client understands how this medication works?
 
  1. Vincristine affects the cells by encouraging rapid division.
  2. The medication is made from plant.
  3. Immunosuppression is a serious and life-threatening adverse effect.
  4. Alopecia is permanent.

[allisonblackmore]

Answer to Question 1

1, 2, 3

Rationale 1: Vinca alkaloids are derived from the periwinkle plant.
Rationale 2: Topoisomerase inhibitors block enzyme topoisomerase isolated from the May apple long plant.
Rationale 3: Taxanes are isolated from the Pacific yew, an evergreen found throughout the western United States.
Rationale 4: Alkylating agents have not been extracted fromplants.
Rationale 5:Antimetabolite agents chemically resemble essential building blocks of the cell. They are not extracted from plants.

Global Rationale: Chemicals with antineoplastic activity have been isolated from a number of plants. These include vinca alkaloids, topoisomerase inhibitors, and taxanes.

Answer to Question 2

2

Rationale 1: Vincristine affects rapidly growing cells by inhibiting their ability to complete mitosis.
Rationale 2: Vincristine is made from a plant extract and is a vinca alkaloid.
Rationale 3: The advantage of vincristine is that it causes minimal immunosuppression.
Rationale 4: Alopecia is reversible.

Global Rationale: Vincristine affects rapidly growing cells by inhibiting their ability to complete mitosis. Although it must be given IV, a major advantage of vincristine is that it causes minimal immunosuppression. Reversible alopecia occurs in most patients.

[ts19998]

Thank you!

[allisonblackmore]

Always glad to help...