Answer to Question 1
1, 2
Rationale 1: Hydralazine (Apresoline) is a vasodilator.
Rationale 2: Isosorbide dinitrate (Isordil) is a vasodilator.
Rationale 3: Lisinopril (Prinivil) is an ACE inhibitor.
Rationale 4: Carvedilol (Coreg) is a beta blocker.
Rationale 5: Furosemide (Lasix) is a loop diuretic.
Global Rationale: Hydralazine (Apresoline) is a vasodilator. Isosorbide dinitrate (Isordil) is a vasodilator. Lisinopril (Prinivil) is an ACE inhibitor. Carvedilol (Coreg) is a beta blocker. Furosemide (Lasix) is a loop diuretic.
Answer to Question 2
2, 3
Rationale 1:Carvedilol (Coreg) should not be used to treat heart failure is incorrect because it is used in combination with ACE inhibitors to treat heart failure.
Rationale 2: Carvedilol (Coreg) has the potential to worsen heart failure.
Rationale 3: Carvedilol (Coreg) slows the heart rate and decreases blood pressure.
Rationale 4:Carvedilol (Coreg) is a first-line drug for treating heart failure is incorrect because the first-line drugs are ACE inhibitors and diuretics.
Rationale 5: Carvedilol (Coreg) is used in combination with other agents, usually ACE inhibitors.
Global Rationale:Carvedilol has been found to reduce symptoms of heart failure, slowing the progression of the disease, and increase exercise tolerance when combined with other drugs for heart failure such as ACE inhibitors. Carvedilol's (Coreg) effect in decreasing heart rate and contractility has the potential to worsen heart failure; therefore, dosage must be carefully monitored.
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Mechanisms of action of drugs used for heart failure.
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