Answer to Question 1
1,2
Rationale 1: The patient should carefully wash hands after administration to prevent inadvertent exposure of the eyes.
Rationale 2: The patient may develop systemic effects if extra medication is swallowed.
Rationale 3: The drug works quickly and should not be used for long periods of time.
Rationale 4: There is no reason for the patient to avoid grapefruit juice.
Rationale 5: While there is no specific treatment for overdose, there is no reason to alarm the patient. Instructions are easy to follow, and overdose is very unlikely.
Global Rationale: The patient should carefully wash hands after administration to prevent inadvertent exposure of the eyes. The patient may develop systemic effects if extra medication is swallowed. The drug works quickly and should not be used for long periods of time. There is no reason for the patient to avoid grapefruit juice. While there is no specific treatment for overdose, there is no reason to alarm the patient. Instructions are easy to follow, and overdose is very unlikely.
Answer to Question 2
3
Rationale 1: The kidney does not have an anatomical barrier that limits some drugs from gaining access.
Rationale 2: The liver does not have an anatomical barrier that limits some drugs from gaining access.
Rationale 3: The brain, testes, and placenta all have barriers that limit the movement of some drugs from the bloodstream into those organs.
Rationale 4: The heart does not have an anatomical barrier that limits some drugs from gaining access.
Global Rationale: The brain, testes, and placenta all have barriers that restrict the movement of some drugs from the bloodstream into those organs. The kidneys, liver, and heart have no anatomical barriers to limit some drugs from gaining access.