A patient newly diagnosed with tuberculosis asks the nurse why ...

[audragclark]

A patient newly diagnosed with tuberculosis asks the nurse why oral medications must be given in the clinic. The nurse will tell the patient that medications are given in the clinic so that:
 
  a. clinic staff can observe adherence to drug regimens.
  b. nurses can monitor for drug toxicities.
  c. providers can adjust doses as needed.
  d. the staff can ensure that the U.S. Food and Drug Administration (FDA) regulations are met.

Question 2

A patient with HIV who takes protease inhibitors develops tuberculosis and will begin treatment. Which drug regimen will be used for this patient?
 
  a. Isoniazid, pyrazinamide, ethambutol + rifabutin
  b. Isoniazid, pyrazinamide, ethambutol
  c. Isoniazid, rifampin, pyrazinamide, ethambutol
  d. Isoniazid + rifabutin

[TheNamesImani]

Answer to Question 1

ANS: A
Adherence to drug regimens is a serious problem in the treatment of TB. Directly observed therapy (DOT) combined with intermittent dosing helps ensure adherence and increases the chance of success. Patients report drug side effects to providers; it is not necessary to give drugs in the clinic to monitor this. Doses are adjusted based on response to treatment and not on DOT. The FDA regulations do not require DOT.

Answer to Question 2

ANS: A
Patients with HIV who take protease inhibitors are susceptible to drug interactions with rifampin, which accelerates the metabolism of protease inhibitors. Rifabutin can be substituted for rifampin in patients with HIV, because the degree of acceleration of this metabolism is less. A three-drug regimen would increase drug resistance, as would a two-drug regimen.

[audragclark]

Thanks for the timely response, appreciate it

[Sarahjh]

Gracias!