Author Question: A client is receiving medroxyprogesterone (Provera) for secondary amenorrhea. Which medications ... (Read 16 times)

mmm · **on:** Jul 23, 2018

A client is receiving medroxyprogesterone (Provera) for secondary amenorrhea. Which medications would be contraindicated for this client?

Standard Text: Select all that apply.
1. Barbiturates
2. Rifampin
3. Topiramate
4. Acetaminophen
5. Furosemide

Question 2

A client is being considered for progestin therapy. However, the nurse is concerned because of which risk factors?

Standard Text: Select all that apply.
1. Current age 39
2. Being treated for atrial fibrillation
3. Smoking
4. Sedentary lifestyle
5. Vegetarian diet

Jsherida · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 1,2,3
Rationale 1: Serum levels of medroxyprogesterone are decreased by barbiturates.
Rationale 2: Serum levels of medroxyprogesterone are decreased by rifampin.
Rationale 3: Serum levels of medroxyprogesterone are decreased by topiramate.
Rationale 4: Acetaminophen does not affect medroxyprogesterone .
Rationale 5: Furosemide does not affect medroxyprogesterone .
Global Rationale: Serum levels of medroxyprogesterone are decreased by aminoglutethimide, barbiturates, primidone, rifampin, rifabutin, and topiramate. Acetaminophen and furosemide do not have this effect.

Answer to Question 2

Correct Answer: 1,2,3
Rationale 1: The risk for thromboembolic events with progestin increases over the age of 35.
Rationale 2: The risk for thromboembolic events with progestin increases in those with cardiovascular disease.
Rationale 3: The risk for thromboembolic events with progestin increases in those who smoke.
Rationale 4: A sedentary lifestyle does not increase the risk for side or adverse effects of progestin therapy.
Rationale 5: A vegetarian diet does not increase the risk for side or adverse effects of progestin therapy.
Global Rationale: The risk for thromboembolic events with progestin increases over the age of 35, in those with cardiovascular disease, and in those who smoke. Sedentary lifestyle and being vegetarian does not increase this risk.