Answer to Question 1
Correct Answer: 2
Rationale 1: Warfarin does not accelerate the metabolism of levothyroxine.
Rationale 2: Phenytoin accelerates the metabolism of levothyroxine.
Rationale 3: Antacids do not accelerate the metabolism of levothyroxine.
Rationale 4: Calcium does not accelerate the metabolism of levothyroxine.
Global Rationale: Phenytoin accelerates the metabolism of levothyroxine. Levothyroxine changes the metabolism of warfarin. Calcium and digoxin reduce the effects of levothyroxine.
Answer to Question 2
Correct Answer: 1,3,5
Rationale 1: The manifestations of myxedema coma include edema of the face and eyes.
Rationale 2: Tachycardia is not a manifestation of myxedema coma.
Rationale 3: The manifestations of myxedema coma include hypoglycemia.
Rationale 4: Hyperthermia is not a manifestation of myxedema coma.
Rationale 5: The manifestations of myxedema coma include hypoventilation.
Global Rationale: Findings associated with myxedema coma include edema of the face and eyes, hypoglycemia, and hypoventilation. Tachycardia and hyperthermia are more related to hyperthyroidism.