Author Question: The nurse is explaining the mechanisms of action for alkylating agents and states that alkylating ... (Read 56 times)

nautica902 · **on:** Jul 23, 2018

The nurse is explaining the mechanisms of action for alkylating agents and states that alkylating agents kill cancer cells by:

Standard Text: Select all that apply.
1. altering the shape of the DNA double helix.
2. preventing the DNA from duplicating during cell division.
3. becoming incorporated into the DNA of cancer cells.
4. interfering with DNA replication and function.
5. an unknown mechanism of action.

Question 2

A common theme among all the antineoplastic agents is:

1. their adverse effects.
2. their ability to kill cancer cells.
3. their drug interactions.
4. their mechanism of action.

mochi09 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 1,2
Rationale 1: Alkylating agents alter the shape of the DNA double helix.
Rationale 2: Alkylating agents prevent the DNA from duplicating during cell division.
Rationale 3: This is the mechanism of action for antimetabolites.
Rationale 4: This is the mechanism of action for antimetabolites.
Rationale 5: The mechanism of hormone antineoplastic activity is largely unknown.
Global Rationale: Alkylating agents change the shape of the deoxyribonucleic acid double helix and prevent cancer cells from dividing normally. Antimetabolites become incorporated into the DNA interfering with replication and function. The mechanism of action of alkylating agents is known.

Answer to Question 2

Correct Answer: 2
Rationale 1: A common theme of all antineoplastic agents is not their adverse effects, even though some might have some similar side effects.
Rationale 2: A common theme of all antineoplastic agents is their toxicitytheir ability to kill cancer cells.
Rationale 3: A common theme of all antineoplastic agents is not their drug interactions.
Rationale 4: A common theme of all antineoplastic agents is not their mechanism of action.
Global Rationale: The commonality among antineoplastic agents is their ability to kill cancer cells. Not all have the same adverse effects, they interact differently with other drugs, and have different mechanisms of action.