Answer to Question 1
Correct Answer: 4
Rationale 1: Nausea can occur but does not require immediate reporting to the provider.
Rationale 2: Tinnitus is not an adverse effect of chloroquine.
Rationale 3: Diarrhea, should it occur, would not need to be reported immediately.
Rationale 4: Blurred vision could indicate retinal toxicity and should be reported immediately.
Global Rationale: Patients with preexisting retinal field changes should not receive chloroquine, because the drug concentrates in this tissue and high doses can cause irreversible retinal damage. Baseline and periodic vision screening should be conducted during therapy. Nausea and diarrhea can occur, but do not require notification of the provider. Tinnitus is not an adverse effect of this drug.
Answer to Question 2
Correct Answer: 1,2
Rationale 1: Pyrimethamine can stimulate the CNS and cause seizures.
Rationale 2: Serious adverse effects such as folic acid deficiency, megaloblastic anemia, pancytopenia, thrombocytopenia, and leukopenia may occur.
Rationale 3: Nausea is a common adverse effect and would not require the drug to be discontinued.
Rationale 4: Vomiting is a common adverse effect and would not require the drug to be discontinued.
Rationale 5: Anorexia is a common adverse effect and would not require the drug to be discontinued.
Global Rationale: Pyrimethamine can stimulate the CNS and cause seizures. Serious adverse effects such as folic acid deficiency, megaloblastic anemia, pancytopenia, thrombocytopenia, and leucopenia may occur. Nausea, vomiting, and anorexia are common adverse effects and would not require the drug to be discontinued.