Answer to Question 1
Correct Answer: 2
Rationale 1: The risk for nephrotoxicity is increased if nephrotoxic drugs are prescribed concurrently.
Rationale 2: Concurrent use of more than one ototoxic drug increases the risk of hearing impairment.
Rationale 3: Pseudomembranous colitis is a serious adverse effect associated with tetracycline.
Rationale 4: Photosensitivity is associated with protein synthesis inhibitors, but not with calcium channel blockers or salicylates.
Global Rationale: Concurrent use of more than one ototoxic drug increases the risk of hearing impairment.
The risk for nephrotoxicity is increased if nephrotoxic drugs are prescribed concurrently. Pseudomembranous colitis is a serious adverse effect associated with tetracycline. Photosensitivity is associated with protein synthesis inhibitors, but is not potentiated by addition of furosemide.
Answer to Question 2
Correct Answer: 1,2,3
Rationale 1: Food, especially milk or diary products, decreases the absorption of tetracycline.
Rationale 2: Tetracycline does cause photosensitivity that makes the skin more susceptible to sunburn.
Rationale 3: Women on oral contraceptives and tetracycline have a higher incidence of vaginal yeast infections.
Rationale 4: Tetracycline is contraindicated in pregnancy because it can cause brown stains on the baby's teeth.
Rationale 5: Tetracycline-induced diarrhea is common, but the possibility of pseudomembranous colitis must be promptly ruled out.
Global Rationale: Adverse effects of tetracycline include photosensitivity and a higher incidence of vaginal yeast infections when taken concurrently with oral contraceptives. Food decreases absorption. Diarrhea is a common adverse effect, but should be assessed for the presence of pseudomembranous colitis. Tetracycline is contraindicated in pregnancy because it can cause brown stains on the baby's teeth.