Author Question: In which situation is it appropriate for the nurse to instruct the client to stop taking minocycline ... (Read 156 times)

craiczarry · **on:** Jul 23, 2018

In which situation is it appropriate for the nurse to instruct the client to stop taking minocycline (Minocin) and promptly seek medical advice?

1. The client reports epigastric burning.
2. The client reports dizziness and vertigo.
3. The client reports vaginal discharge.
4. The client reports occasional nausea.

Question 2

A client reports no improvement after 5 days of therapy with tetracycline. The nurse suspects drug resistance and knows that drug resistance can develop in which ways?

Standard Text: Select all that apply.
1. A drug is prevented from concentrating inside the bacterial cell.
2. A broad-spectrum antibacterial drug is used instead of a narrow-spectrum drug.
3. A bacteriostatic agent is paired with a bacteriocidal agent.
4. Bacteria acquire the ability to degrade the antibiotic.
5. The shape of the bacteria mutates and prevents an antibiotic from binding to it.

ms_sulzle · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 2
Rationale 1: Epigastric burning is a common side effect but does not require discontinuation of the drug.
Rationale 2: Minocycline is the only tetracycline that can cause reversible vestibular toxicity. Symptoms include dizziness, vertigo, and weakness.
Rationale 3: Vaginal discharge may be a symptom of a yeast infection and should be evaluated for treatment, but most likely does not require discontinuation of the drug.
Rationale 4: Occasional nausea is a common side effect but does not require discontinuation of the drug.
Global Rationale: Minocycline is the only tetracycline that can cause reversible vestibular toxicity. Symptoms include dizziness, vertigo, and weakness. Occasional nausea and epigastric burning are common side effects but do not require discontinuation of the drug. Vaginal discharge may be a symptom of a yeast infection and should be evaluated for treatment, but most likely does not require discontinuation of the drug.

Answer to Question 2

Correct Answer: 1,2,4,5
Rationale 1: Resistance can develop when a drug is prevented from concentrating within the bacterial cell.
Rationale 2: Broad-spectrum antibacterial agents are associated with bacterial drug resistance. Narrow-spectrum drugs should be used whenever the bacterial organism is known.
Rationale 3: Pairing bacteriostatic and bacteriocidal agents is a strategy used to reduce the development of resistant strains.
Rationale 4: A shortened duration of therapy can lead to development of resistant strains of bacteria.
Rationale 5: Altering the shape of the bacterial ribosome can prevent an antibiotic from binding to the ribosome.
Global Rationale: Resistance, the ability of an organism to degrade the antibiotic, can develop when a drug is prevented from concentrating within the bacterial cell. Broad-spectrum antibacterial agents are associated with bacterial drug resistance. Narrow-spectrum drugs should be used whenever the bacterial organism is known. Pairing bacteriostatic and bacteriocidal agents is a strategy used to reduce the development of resistant strains. Altering the shape of the bacterial ribosome can prevent an antibiotic from binding to the ribosome.