Answer to Question 1
Correct Answer: 1,2
Rationale 1: This is a mechanism of action of amphetamines.
Rationale 2: This is a mechanism of action for cocaine.
Rationale 3: This is not a mechanism of action for either cocaine or amphetamines.
Rationale 4: This is not a mechanism of action for either cocaine or amphetamines.
Rationale 5: This is not a mechanism of action for either cocaine or amphetamines.
Global Rationale: Stimulating the release of norepinephrine on the presynaptic neuron is the mechanism of action for amphetamines. Inhibiting the reuptake of norepinephrine from the synaptic cleft back to the presynaptic neuron is the mechanisms of action for cocaine. The other statements do not indicate a mechanism of action for either cocaine or amphetamines.
Answer to Question 2
Correct Answer: 2
Rationale 1: Ephedrine, when given orally, is readily absorbed from the GI tract and crosses the blood brainbarrier. It exhibits prominent stimulatory effects in the brain, keeping the patient alert and awake.
Rationale 2: Ephedrine can be used in bronchial asthma because of beta-2 receptor stimulation. It also stimulates beta-1 and alpha receptors, which causes cardiac side effects.
Rationale 3: Ephedrine does not cause excessive vomiting.
Rationale 4: Ephedrine does not cause increased appetite.
Global Rationale: Ephedrine can be used in bronchial asthma because of beta-2 receptor stimulation. It also stimulates beta-1 and alpha receptors, which causes cardiac side effects. Ephedrine, when given orally, is readily absorbed from the GI tract and crosses the blood brainbarrier. It exhibits prominent stimulatory effects in the brain, keeping the patient alert and awake. Ephedrine does not cause excessive vomiting or an increase in appetite.