Answer to Question 1
Correct Answer: 4
Rationale 1: Heart attacks are more common in women later in life. Men are affected early in the lifespan.
Rationale 2: Some medications affect gender differently, based on the different expression of the genes.
Rationale 3: Aspirin is more effective in preventing heart attacks in men than in women.
Rationale 4: Aspirin is more effective in preventing heart attacks in men than in women.
Global Rationale: Aspirin is more effective in preventing heart attacks in men than in women. Heart attacks are more common in women later in life. Men are affected early in the lifespan. Some medications affect gender differently, based on the different expression of the genes.
Answer to Question 2
Correct Answer: 1,2,3
Rationale 1: There was a lack of ethnic diversity in early clinical trials.
Rationale 2: Until recently, clinical trials comprised mostly Caucasian males.
Rationale 3: Little attention was focused on identifying the differences in pharmacologic effects in diverse ethnic groups.
Rationale 4: There was insufficient research to show differences because little attention was focused on these differences.
Rationale 5: The large majority of clinical trials excluded females.
Global Rationale: There was a lack of ethnic diversity in early clinical trials. Until recently, clinical trials comprised mostly Caucasian males. Little attention was focused on identifying the differences in pharmacologic effects in diverse ethnic groups. There was insufficient research to show differences because little attention was focused on these differences. The large majority of clinical trials excluded females.