Author Question: The nurse is preparing to administer felodipine to a hospitalized client. The nurse assesses the ... (Read 81 times)

anshika · **on:** Jul 23, 2018

The nurse is preparing to administer felodipine to a hospitalized client. The nurse assesses the client for which disorders that may cause an increased risk for adverse effects associated with this medication due to its extended half-life?

1. Renal disease
2. Liver disease
3. Gastrointestinal disease
4. Cardiac disease
5. Pulmonary disease

Question 2

A client has been started on a medication for postoperative pain. When does the nurse anticipate the client will receive optimal pain relief?

1. When the drug concentrates in the muscle tissue
2. When the drug reaches a therapeutic range
3. When the drug achieves a minimal effective concentration
4. When the drug approaches a toxic concentration

CourtneyCNorton · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 1,2
Rationale 1: As drugs stay in the body for prolonged periods, the risk for long-term adverse effects increases. This can become particularly serious for clients with significant renal impairment; diminished metabolism and excretion will cause the plasma half-life of a drug to increase, and the concentration may reach toxic levels.
Rationale 2: As drugs stay in the body for prolonged periods, the risk for long-term adverse effects increases. This can become particularly serious for clients with significant hepatic impairment; diminished metabolism and excretion will cause the plasma half-life of a drug to increase, and the concentration may reach toxic levels.
Rationale 3: Gastrointestinal disease does not increase the risk of adverse drug effects.
Rationale 4: Cardiac disease does not increase the risk of adverse drugs effects.
Rationale 5: Pulmonary disease does not increase the risk of adverse drug effects.
Global Rationale: As drugs stay in the body for prolonged periods, the risk for long-term adverse effects increases. This can become particularly serious for clients with significant renal impairment; diminished metabolism and excretion will cause the plasma half-life of a drug to increase, and the concentration may reach toxic levels. Gastrointestinal disease does not increase the risk of adverse drug effects. Cardiac disease does not increase the risk of adverse drugs effects. Pulmonary disease does not increase the risk of adverse drug effects.

Answer to Question 2

Correct Answer: 2
Rationale 1: The drug does not have to concentrate in muscle tissue in order to relieve pain.
Rationale 2: The goal of therapy is to reach and maintain a plasma level in the therapeutic range.
Rationale 3: The client might experience some pain relief at a minimum effective concentration but probably not optimal pain relief.
Rationale 4: A toxic concentration does not need to be reached in order to achieve pain relief; in fact, it should be avoided.
Global Rationale: The goal of therapy is to reach and maintain a plasma level in the therapeutic range. The drug does not have to concentrate in muscle tissue in order to relieve pain. The client might experience some pain relief at a minimum effective concentration but probably not optimal pain relief. A toxic concentration does not need to be reached in order to achieve pain relief; in fact, it should be avoided.