Some of the drugs used to treat HIV patients are competitive inhibitors of the HIV reverse transcriptase enzyme. Unfortunately, the high mutation rate of HIV means that the virus rapidly acquires mutations with amino acid changes that make them resistant to these competitive inhibitors. Where in the reverse transcriptase enzyme would such amino acid changes most likely occur in drug-resistant viruses?
A) in or near the active site
B) at an allosteric site
C) at a cofactor binding site
D) in regions of the protein that determine packaging into the virus capsid
E) such mutations could occur anywhere with equal probability
Patients should be encouraged to bring to their health care visit all the substances that they take,
Drugs Commonly Stocked in an Emergency Medical Box
Injectable Drugs Commonly Stocked in the Medical Office
Drugs for Female Infertility
Device to deliver repository drugs
Antibiotic Inhibitors of Protein Synthesis