A client is taking a drug that is moderately highly protein ...

[panfilo]

A client is taking a drug that is moderately highly protein bound. Several days later, the client takes a second drug that is 90 protein bound. What is most likely to have occurred as a result of this administration?
 
  a. The first drug remains protein bound.
  b. The first drug becomes increasingly inactive.
  c. The first drug is released from the protein and becomes more pharmacologically active.
  d. The second drug becomes more active.

Question 2

A nurse is determining whether a medication is ordered to be given at the appropriate intervals. This is done by assessing the half-life of the medication. The serum half-life (t ) of a drug is the time required:
 
  a. for half of a drug dose to be absorbed.
  b. after absorption for half of the drug to be eliminated.
  c. for a drug to be achieve maximum effectiveness.
  d. for half of the drug dose to be completely distributed.

[jaymee143]

Answer to Question 1

ANS: C
Only drugs not bound to protein are active and can cause a pharmacologic response. As the free drug in the circulation decreases, more bound drug is released from the protein to maintain the balance of free drug.

Answer to Question 2

ANS: B
The half-life (t ) of a drug is the time it takes for one half of the drug concentration to be eliminated.

[panfilo]

TYSM

[Joy Chen]

Excellent