A patient with a history of congestive heart failure and renal ...

[Pineappleeh]

A patient with a history of congestive heart failure and renal impairment has esophageal candidiasis. Which antifungal agent would the nurse anticipate giving to this patient?
 
  a. Amphotericin B Abelcet
  b. Fluconazole Diflucan
  c. Itraconazole Sporanox
  d. Voriconazole Vfend

Question 2

A nursing student asks a nurse to explain the differences between amphotericin B Abelcet and the azoles group of antifungal agents. Which statement by the nurse is correct?
 
  a. Amphotericin B can be given orally or intravenously.
  b. Amphotericin B increases the levels of many other drugs.
  c. Azoles have lower toxicity than ampho-tericin B.
  d. Only the azoles are broad-spectrum anti-fungal agents.

[Sammyo]

Answer to Question 1

B
Fluconazole is a drug of choice for treating systemic candidal infections. Amphotericin is neph-rotoxic and should not be used in patients with existing renal disease. Itraconazole is a possible alternative agent for treating candidiasis but has serious cardiac side effects. Voriconazole is a drug of first choice for treating aspergillosis but not for candidiasis.

Answer to Question 2

C
The azoles class of antifungals is less toxic than amphotericin B. Amphotericin B may only be given parenterally. The azoles, not amphotericin B, inhibit hepatic P450 drug-metabolizing en-zymes, so they increase the levels of many other drugs. Both classes are broad-spectrum anti-fungal agents.

[Pineappleeh]

Thanks for the timely response, appreciate it

[lkanara2]

TYSM