Answer to Question 1
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Answer to Question 2
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Adverse effects of isotretinoin can be increased by tetracycline, so tetracycline must be discon-tinued before therapy is started. Alcohol should be avoided, since it can potentiate hypertriglyce-ridemia. Skin rash, headache, and hair loss are not common side effects, although they can occur. Two pregnancy tests are required at the beginning of therapy; at each refill, only one pregnancy test is required.