Answer to Question 1
A
Spironolactone prolongs survival in patients with HF primarily by blocking receptors for aldos-terone. Spironolactone cause only minimal diuresis. It does not reduce afterload, and it does not reduce venous pressure enough to prolong survival, because it causes only minimal diuresis.
Answer to Question 2
A
Avanafil is used to treat ED and, unlike the other agents, has a shorter onset of action, with ef-fects occurring in 15 minutes after taking the drug and may be taken 30 minutes prior to inter-course. The other agents must be taken 2 hours prior to intercourse.