Author Question: After administering propylthiouracil (PTU), what effect would the nurse anticipate the drug will ... (Read 19 times)

evelyn o bentley · **on:** Jul 23, 2018

After administering propylthiouracil (PTU), what effect would the nurse anticipate the drug will have in the patient's body?

A) To destroy part of the thyroid gland
B) To inhibit production of thyroid hormone in the thyroid gland
C) To suppress the anterior pituitary gland's secretion of thyroid-stimulating hormone (TSH)
D) To suppress the hypothalamus's production of thyrotropin-releasing hormone (TRH)

Question 2

The nurse attends a class on preventing resistance to anti-infectives and learns that the critical concept in preventing the development of resistant strains of microbes is what?

A) Exposure of pathogens to an antimicrobial agent without cellular death
B) Drug dosages that are below a therapeutic level
C) The duration of drug use
D) Frequency of drug ingestion

johnpizzaz · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

B
Feedback:
PTU is a thioamide that acts by lowering thyroid hormone levels by preventing the formation of thyroid hormone in the thyroid cells, which lowers the serum levels of thyroid hormone. They also partially inhibit the conversion of thyroxine to triiodothyronine at the cellular level. Iodine solutions oversaturate thyroid cells and top production of thyroid hormone. Radioactive iodine destroys part of the thyroid gland. PTU does not impact production or secretion of TSH or TRH.

Answer to Question 2

C
Feedback:
Exposure of pathogens to an antimicrobial agent without cellular death leads to the development of resistance so it is important to limit the use of these agents to treat pathogens with a known sensitivity to the drug being used. Drug dosages are also important in preventing the development of resistance. However, the duration of drug use is critical to ensure that microbes are completely eliminated and not given the chance to grow and develop resistant strains. It is hard to convince patients that they must always complete the entire course of antimicrobial agents when they begin to feel better, because stopping early favors the emergence of drug-resistant strains.