A nurse is explaining to the parents of a 6-year-old child suffering from angina why nitroglycerin patches for chest pain would not be appropriate. Which of the following will the nurse include in an explanation?
A) A child has an erratic blood flow from an immature peripheral circulation, which increases drug absorption, causing an increase in adverse effects.
B) A child's gastric pH is decreased, causing less of the drug to be absorbed from the subcutaneous skin, therefore producing more adverse effects.
C) A child has a greater body surface area, creating greater permeability resulting in an increase in absorption of topical agents, which may result in more adverse effects.
D) A child has a smaller body surface area, resulting in an increase in topical absorption, which can cause more adverse effects.
Question 2
Which of the following patients would the nurse determine has the highest risk of cumulative toxicity if prescribed colchicine?
A) A pregnant patient
B) A patient with hepatic disease
C) A patient undergoing radiation therapy
D) A patient with myelosuppression
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