Answer to Question 1
ANS: D
The symptoms of hepatotoxicity are anorexia, nausea, vomiting, jaundice, hepatomegaly, splenomegaly, and abnormal liver function test results (elevated bilirubin, aspartate aminotransferase AST, ALT, gamma-glutamyl transpeptidase GGT, alkaline phosphatase, prothrombin time). Bilirubin increases with hepatotoxicity. Albumin decreases with hepatotoxicity. Alkaline phosphatase increases with hepatotoxicity.
Answer to Question 2
ANS: A
Cholinergic agents cause a slowing of the heart. The health care provider should be notified if the heartbeat is regularly less than 60 beats/min. Vomiting, diarrhea, and dyspepsia are common adverse effects of donepezil (Aricept) and should subside after 2 to 3 weeks of therapy.